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Synthesis of Amphiphilic Comb‐Shape Copolymers Via Ring‐Opening Polymerization of a Macromonomer
Author(s) -
Zhang Xiaojin,
Zhang Zhenguo,
Su Xin,
Dong Hui,
Zhong Zhenlin,
Zhuo Renxi
Publication year - 2015
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201500161
Subject(s) - macromonomer , copolymer , micelle , polymer chemistry , amphiphile , caprolactone , polymerization , materials science , ethylene glycol , ring opening polymerization , dynamic light scattering , trimethylene carbonate , chemistry , nanoparticle , aqueous solution , polymer , organic chemistry , nanotechnology , composite material
Amphiphilic comb‐shape copolymers PCL‐ co ‐P(MTC‐mPEG 16 ) (where PCL, MTC, and mPEG refer to poly(ε‐caprolactone), 2‐methyltrimethylene carbonate, and methoxy poly(ethylene glycol), respectively) are synthesized by ring‐opening polymerization of ε ‐caprolactone and cyclic carbonate‐terminated PEG macromonomer (MTC‐mPEG 16 ) with benzyl alcohol as an initiator and Sn(Oct) 2 as a catalyst. Amphiphilic copolymers PCL‐ co ‐P(MTC‐mPEG 16 ) can form micelles in aqueous solution by self‐assembly. The diameters of PCL‐ co ‐P(MTC‐mPEG 16 ) micelles characterized by dynamic light scattering area few dozens of nanometers with a narrow size distribution and the morphology of the micelles observed through transmission electron microscopy are nanosized spheres. The in vitro drug release of comb‐shape copolymer PCL‐ co ‐P(MTC‐mPEG 16 ) micelles is more stable and sustained than that of linear block copolymers mPEG‐ b ‐PCL.