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Photocrosslinkable Poly(ε‐caprolactone)‐ b ‐Hyperbranched Polyglycerol (PCL‐ b ‐hbPG) with Improved Biocompatibility and Stability for Drug Delivery
Author(s) -
Kim YongJin,
Kim Bongsoo,
Hyun Dong Choon,
Kim Jin Woong,
Shim HyeEun,
Kang SunWoong,
Jeong Unyong
Publication year - 2015
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201500047
Subject(s) - biocompatibility , nanocarriers , drug delivery , caprolactone , amphiphile , nanoparticle , chemistry , copolymer , materials science , polymer chemistry , nanotechnology , organic chemistry , polymer
The major limitations of nanocarriers for drug delivery are the poor biocompatibility and low stability that may induce the unintended burst release of loaded drugs during blood circulation. To overcome these limitations, a photocrosslinkable amphiphilic block copolymer consisting of hydrophobic poly(ε‐caprolactone) (PCL) block and a hydrophilic hyperbranched polyglycerol (hbPG) block with improved biocompatibility and stability for drug delivery is developed. They are readily prepared via UV‐triggered chemical crosslinking with 4‐hydroxycinnamic acid (CA) modification in the hbPG block. The photocrosslinked hbPG‐ b ‐PCL‐CA nanoparticles are spherical and the size of nanoparticles is increased to 60 ± 30 nm. Photocrosslinked hbPG‐ b ‐PCL‐CA nanoparticles exhibit significantly high stability in a physiological buffer and the loaded drug in sustained manner. In addition, photocrosslinked hbPG‐ b ‐PCL‐CA nanoparticles show good biocompatibility in vitro and in vivo. These data imply the promising potential of photocrosslinked hbPG‐ b ‐PCL‐CA nanoparticles as nanocarriers for drug delivery.