Premium
In Vitro Platelet Adhesion of PNaAMPS/PAAm and PNaAMPS/PDMAAm Double‐Network Hydrogels
Author(s) -
Zheng Wen Jiang,
Liu Zhen Qi,
Xu Feng,
Gao Jie,
Chen Yong Mei,
Gong Jian Ping,
Osada Yoshihito
Publication year - 2015
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201400481
Subject(s) - self healing hydrogels , biocompatibility , adhesion , protein adsorption , zeta potential , polymer chemistry , chemistry , platelet , acrylamide , adsorption , platelet activation , materials science , chemical engineering , nanotechnology , polymer , copolymer , organic chemistry , immunology , nanoparticle , engineering , biology
Nowadays, tough double‐network (DN) hydrogels have attracted great attention owing to their excellent mechanical properties and good biocompatibility, which give them the potential to be used as blood‐contacting soft tissue prostheses and medical devices. However, the study of platelet adhesion behavior on the surface of DN hydrogels has not been reported yet. In this work, the human platelet adhesion on the surface of poly (sodium 2‐acrylamido‐2‐methyl‐propanesulfonate) PNaAMPS/poly acrylamide (PAAm) and PNaAMPS/poly ( N , N′ ‐dimethylacrylamide) (PDMAAm) DN hydrogels is investigated under static conditions in vitro. The numbers of adherent platelets on PNaAMPS/PAAm and PNaAMPS/PDMAAm hydrogels are 16 ± 7 and 9 ± 8 cells per 10 4 μm 2 , respectively, which are far less than 297 ± 41 cells per 10 4 μm 2 on polyethylene terephthalate (PET) and 187 ± 26 cells per 10 4 μm 2 on negatively charged PNaAMPS (4 mol%) hydrogel. The results indicate the excellent antiplatelet performance of DN hydrogels. Moreover, the platelet adhesion mechanism is also discussed. The platelet adhesion is affected by the chemical component, zeta potential, and serum proteins adsorption of the hydrogel.