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Stimuli‐Induced Core–Corona Inversion of Micelle of Poly(acrylic acid)‐ block ‐Poly( N ‐isopropylacrylamide) and Its Application in Drug Delivery
Author(s) -
Bastakoti Bishnu Prasad,
Guragain Sudhina,
Nakashima Kenichi,
Yamauchi Yusuke
Publication year - 2015
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201400440
Subject(s) - acrylic acid , lower critical solution temperature , poly(n isopropylacrylamide) , micelle , copolymer , polymer chemistry , polymer , drug delivery , acrylic polymer , nile red , chemistry , chemical engineering , materials science , monomer , organic chemistry , fluorescence , aqueous solution , physics , quantum mechanics , engineering
Core–corona inversion of micelles of diblock copolymer poly(acrylic acid)‐ block ‐poly(N‐isopropylacrylamide) (PAA‐ b ‐PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH‐sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.