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Layer‐by‐Layer Coated PLA Nanoparticles with Oppositely Charged β‐Cyclodextrin Polymer for Controlled Delivery of Lipophilic Molecules
Author(s) -
El Fagui Amani,
Wintgens Véronique,
Gaillet Christine,
Dubot Pierre,
Amiel Catherine
Publication year - 2014
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201300693
Subject(s) - cyclodextrin , dynamic light scattering , polymer , nanoparticle , layer by layer , chemistry , molecule , chemical engineering , polymer chemistry , benzophenone , x ray photoelectron spectroscopy , layer (electronics) , adsorption , controlled release , materials science , nanotechnology , organic chemistry , engineering
The preparation of novel nanoparticles is described, which consist of a poly(lactic acid) (PLA) core obtained by the nanoprecipitation method with a shell made of oppositely charged β‐cyclodextrin polymer (poly‐β‐CD) assembled using the layer‐by‐layer technique. Characterization of these nanoparticles is accomplished through dynamic light scattering, ζ‐potential measurements, X‐ray photoelectron spectroscopy and electron microscopy. The release of a loaded lipophilic molecule, benzophenone (BP), is mainly controlled by diffusion of BP and by its host–guest interaction with the β‐CD cavities of the adsorbed poly‐β‐CD. Increasing the number of poly‐β‐CD layers results in a better control of the release through the partition equilibrium between free BP and BP included in the cavities inside the multilayers.