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A New Thermosensitive Poly( N ‐propionyl‐aspartic acid/ethylene glycol) with No Cytotoxicity and Tunable UCST
Author(s) -
Di Yingying,
Ma Xin,
Li Chunxiu,
Liu Hongmei,
Fan Xueying,
Wang Meng,
Deng Heying,
Jiang Ting,
Yin Ziming,
Deng Kuilin
Publication year - 2014
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201300687
Subject(s) - ethylene glycol , upper critical solution temperature , monomer , aspartic acid , polymer chemistry , polymer , chemistry , fourier transform infrared spectroscopy , cytotoxicity , materials science , nuclear chemistry , organic chemistry , chemical engineering , lower critical solution temperature , amino acid , copolymer , biochemistry , engineering , in vitro
A new thermosensitive poly( N ‐propionyl‐aspartic acid/ethylene glycol) (PPAE) with no cytotoxicity and an upper critical solution temperature (UCST) is synthesized by polycondensation of l ‐aspartic acid and ethylene glycol. The chemical structures of the monomer and polymer are confirmed by FTIR and 1 H NMR spectroscopy, and by elemental analysis measurements. Turbidimetric measurements indicate that PPAE shows a reversible UCST phase transition at 1.5–37.6 °C in pure water or an alcohol/water mixture. The UCST can be facilely tuned via changing the content of alcohol in water or the normal saline. Moreover, the survival rate of HeLa cells to PPAE is close to 100% within 48 h, demonstrating no cytotoxicity. Such aspartic acid‐based polymers with tunable thermosensitivity could be useful in the biomedical field.