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Convenient Synthesis of a Polyester‐ co ‐Polyether Block for Assembling Biocompatible Hyperbranched Macromolecules
Author(s) -
Elkin Igor,
Hildgen Patrice
Publication year - 2014
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201300578
Subject(s) - dendrimer , pentaerythritol , polyester , macromolecule , biocompatible material , materials science , yield (engineering) , block (permutation group theory) , polymer chemistry , chemistry , succinic anhydride , polymer science , organic chemistry , biomedical engineering , medicine , biochemistry , geometry , mathematics , fire retardant , metallurgy
Synthesis of a novel multifunctional block based on asymmetrically substituted pentaerythritol, succinic acid, and tetraethylene glycol is reported. The proposed reaction conditions allow selective preparation of the product in high overall yield. The block can be used in the assembly of biocompatible polyester‐ co ‐polyether (PEPE) hyperbranched macromolecules, which allows the product to be considered as a promising intermediate for the development of new biomedical dendrimers. As an example, the use of the “block by block” strategy is employed to obtain a second‐generation dendron. It is shown that the approach is much more efficient than the pathway of step‐by‐step grafting of separate molecular fragments.