Premium
A Novel Bioabsorbable Gel Formed from a Mixed Micelle Solution of Poly(oxyethylene)‐ block ‐poly( L ‐lactide) and Poly(oxyethylene)‐ block‐ poly( D ‐lactide) by Concomitant Stereocomplexation and Chain Extension
Author(s) -
Hsu YuI,
Masutani Kazunari,
Kimura Yoshiharu,
Yamaoka Tetsuji
Publication year - 2013
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201300230
Subject(s) - polymer chemistry , copolymer , lactide , micelle , ring opening polymerization , ethylene glycol , diethylene glycol , chemistry , polymerization , ether , condensation polymer , materials science , polymer , organic chemistry , aqueous solution
Furan‐terminated poly(oxyethylene)‐ block ‐poly(L‐lactide) (MePEG‐PLLA‐F) and poly(oxyethylene)‐ block ‐poly(D‐lactide) (MePEG‐PDLA‐F) are synthesized by ring‐opening polymerization of L‐ and D‐lactides, respectively, in the presence of poly(ethylene glycol) monomethyl ether (MePEG) and the following terminal reaction with furfuryl isocyanate. Their mixed micelle solution turns to gel quickly with stereocomplexation of the enantiomeric PLLA and PDLA. When 1,8‐bis(maleimido)diethylene glycol (BMG) is added to the mixed micelle solution, the gelation is promoted by the terminal coupling of the copolymers driven by the Diels–Alder reaction of the furanyl groups and BMG giving a gel having higher strength.