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Polysaccharide‐Based Polyanion–Polycation–Polyanion Ternary Systems in the Concentrated Regime and Hydrogel Form
Author(s) -
Marsich Eleonora,
Travan Andrea,
Feresini Massimo,
Lapasin Romano,
Paoletti Sergio,
Donati Ivan
Publication year - 2013
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201300057
Subject(s) - biopolymer , self healing hydrogels , chemistry , ternary operation , polysaccharide , chemical engineering , chitosan , supramolecular chemistry , rheology , ternary numeral system , polyelectrolyte , polymer , polymer chemistry , organic chemistry , materials science , crystal structure , computer science , engineering , composite material , programming language , phase (matter)
In the field of bioactive biomaterials, multi‐biopolymer systems are of particular interest as they represent potential extra cellular matrix (ECM) mimics. Ternary mixtures composed of alginate, hyaluronan, and a lactose‐modified chitosan undergo a rheological investigation that reveal the presence of polyanion‐polycation supramolecular structures, which dissolve once the third (polyanion) component is added. Two selected ternary mixtures are used for the preparation of calcium–alginate hydrogels and their mechanical performance and stability are found to be strongly influenced by the relative composition in terms of the two non‐gelling components. The presence in the mixture of bioactive polysaccharides leads to a notable improvement in the proliferation of primary culture of chondrocytes.