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Amphiphilic Unimolecular Nanoparticles Based on a Hyperbranched Polyacrylate Core and a PNIPAm Shell: Synthesis via ATRP and Properties
Author(s) -
Cai Yong,
Liu YuYang
Publication year - 2013
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200598
Subject(s) - amphiphile , atom transfer radical polymerization , acrylate , polymer chemistry , copolymer , ethyl acrylate , nanoparticle , polymerization , polymer , chemistry , radical polymerization , materials science , organic chemistry , nanotechnology
A novel amphiphilic unimolecular nanoparticle, multi‐HPBPEA‐ g‐ PNIPAm, for encapsulation and release of hydrophobic guest molecules, is developed. The polymer shows core–shell architecture and is synthesized from inimer 2‐((2‐bromopropionyl)oxy)ethyl acrylate (BPEA) by atom transfer radical polymerization (ATRP) in three steps. The hydrophobic core (multi‐HPBPEA) is composed of hyperbranched poly(2‐((2‐bromopropionyl)oxy)ethyl acrylate) (HPBPEA), which is synthesized by self‐condensing vinyl polymerization (SCVP) of BPEA. Multi‐HPBPEA‐ g ‐PNIPAm is obtained by multi‐HPBPEA core initiating ATRP of N ‐isopropylacrylamide (NIPAm). The encapsulation behavior of the core of multi‐HPBPEA‐ g ‐PNIPAm in an aqueous solution is investigated by fluorescent spectra. It is found that multi‐HPBPEA‐ g‐ PNIPAm can efficiently encapsulate and release a hydrophobic drug like nifedipine.