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High Intensity Focused Ultrasound Triggered Shape Memory and Drug Release from Biodegradable Polyurethane
Author(s) -
Han Jianjun,
Fei Guoxia,
Li Guo,
Xia Hesheng
Publication year - 2013
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200576
Subject(s) - polyurethane , high intensity focused ultrasound , composite number , materials science , payload (computing) , shape memory alloy , ultrasound , composite material , biomedical engineering , computer science , acoustics , engineering , computer network , network packet , physics
A shape memory biodegradable polyurethane composite is prepared and shape recovery and simultaneous release of embedded copper sulfate are realized by high intensity focused ultrasound (HIFU). The composite shows an excellent HIFU‐controlled shape recovery performance, wherein temporal and spatial control can be realized by switching the HIFU on/off or selecting the place where the ultrasound is focused. The composite shows an excellent HIFU switchable drug release function. The release process of a model payload can be tuned by adjusting the HIFU intensity and time. The shape memory polyurethane shows a rapid enzymatic biodegradation rate. This polyurethane composite has potential applications in minimally invasive interventional therapy devices.