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Disulfide Cross‐Linked Polypeptide Nanogel Conjugated with a Fluorescent Probe as a Potential Image‐Guided Drug‐Delivery Agent
Author(s) -
Xing Tao,
Lai Bin,
Yan Lifeng
Publication year - 2013
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200568
Subject(s) - nanogel , chemistry , conjugated system , ethylene glycol , drug delivery , cyanine , click chemistry , polymer chemistry , fluorescence , nanoparticle , polymerization , combinatorial chemistry , materials science , organic chemistry , nanotechnology , polymer , physics , quantum mechanics
A disulfide cross‐linked PEGylated polypeptide nanogel with a near infrared fluorescence (NIRF) group has been synthesized. At first, a NIRF nanogel precursor is prepared by a ring‐opening polymerization of L ‐cystine‐ N ‐carboxy anhydride with azide‐functionalized poly(ethylene glycol) methyl ether. Alkyne cyanine is then conjugated to the nanogel by a click chemical reaction. The formation of the targeted nanogel is confirmed by a series of characterizations. The anticancer drug doxorubicin can be loaded into the NIRF nanogel by physical encapsulation, and the obtained drug‐loaded NIRF nanoparticle shows reduction‐promoted drug‐release behavior in the presence of 10 mM glutathione. The as‐prepared drug‐loaded NIRF nanoparticle has potential applications in the real‐time imaging of drug delivery in vivo.