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New Amphiphilic Conjugates of Amino–Poly(ethylene glycols) With Lipoamino Acids as Surface Modifiers of Colloidal Drug Carriers
Author(s) -
Pignatello Rosario,
Pantò Valentina,
Impallomeni Giuseppe,
Carnemolla Giovanni Marco,
Carbone Claudia,
Puglisi Giovanni
Publication year - 2013
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200476
Subject(s) - chemistry , amphiphile , ethylene glycol , liposome , differential scanning calorimetry , dipalmitoylphosphatidylcholine , peg ratio , vesicle , polymer chemistry , conjugate , drug carrier , polymer , amine gas treating , organic chemistry , drug delivery , copolymer , membrane , phospholipid , phosphatidylcholine , biochemistry , mathematical analysis , physics , mathematics , finance , economics , thermodynamics
Poly(ethylene glycol) (PEG2000) polymers containing one or two amine residues are linked to α‐lipoamino acids (LAA) to produce mono‐ and homo‐disubstituted PEG–LAA conjugates as new materials for the surface coating of colloidal drug carriers. Conjugates are characterized by FT‐IR, 1H‐NMR, and MALDI–TOF mass spectrometry. Differential scanning calorimetry studies are performed to assess the interaction of PEG2000–LAAs with a biomembrane model (dipalmitoylphosphatidylcholine multilamellar liposomes). Whereas the parent PEGs affect only the superficial structure of the bilayers, the amphiphilic PEG–LAA conjugates exert a modulated perturbing effect on the thermotropic profile of liposomes. A molar concentration between 5% and 10% is individuated as the more suitable to produce stable vesicles.