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Polymers as Probes for Multimodal Imaging with MRI
Author(s) -
Thurecht Kristofer J.
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200420
Subject(s) - polymer , molecular imaging , nanotechnology , in vivo , preclinical imaging , materials science , medical imaging , multimodal therapy , imaging agent , computer science , biomedical engineering , artificial intelligence , medicine , biology , surgery , microbiology and biotechnology , composite material
Multimodal imaging agents provide unique opportunities to probe disease states in vivo. The development of polymeric molecular imaging agents that combine the high‐resolution capabilities of MRI with other more sensitive techniques leads to significant possibilities for increasing our understanding of biological processes in live animals. To fully utilise this capability, advanced architectural polymers are being developed in which the material properties of the multimodal imaging agent are underpinned by a strong understanding of the underlying synthetic and physical chemistry of the macromolecules. In this report, the development of new polymers as multimodal imaging agents utilising MRI for preclinical in vivo studies is described.