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Controlled PEGylation of PLA‐Based Nanoparticles
Author(s) -
Ferrari Raffaele,
Yu Yingchuan,
Lattuada Marco,
Storti Giuseppe,
Morbidelli Massimo,
Moscatelli Davide
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200368
Subject(s) - pegylation , macromonomer , copolymer , polymer chemistry , peg ratio , methacrylate , nanoparticle , polymerization , chemistry , materials science , chemical engineering , polyethylene glycol , polymer , nanotechnology , organic chemistry , engineering , finance , economics
The controlled synthesis of degradable nanoparticles (NPs) made from a brush copolymer constituted of a 2‐hydroxyethyl methacrylate (HEMA) backbone with PEG and PLA pendants both tunable in length and composition has been developed. Using ring‐opening polymerization (ROP) of L , L –lactide, vinyl end‐functionalized PLA macromonomers were produced and then copolymerized with HEMA–PEG macromonomers. Narrow dispersed PEGylated NPs with size down to 25 nm with different PEGylation degree and PEG chain lengths were obtained. Surfactant‐free MSSEP in the absence of any solvent was implemented to produce NPs suitable for biomedical applications. The colloidal stability in isotonic solutions of these NPs was investigated and the corresponding critical coagulation concentration (CCC) of the NPs was determined.