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Polymer‐Grafted Silicon Nanoparticles Obtained Either via Peptide Bonding or Click Chemistry
Author(s) -
Maurice Vincent,
Slostowski Cedric,
HerlinBoime Nathalie,
Carrot Geraldine
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200326
Subject(s) - click chemistry , silanization , thermogravimetric analysis , covalent bond , polymer chemistry , ethylene glycol , nanoparticle , azide , materials science , chemical engineering , polymer , surface modification , chemistry , peg ratio , self healing hydrogels , nanotechnology , organic chemistry , engineering , finance , economics
Pegylated silicon nanoparticles (SiNPs) are of great interest for applications in bio‐imaging as fluorescent tracers. Poly(ethylene glycol) (PEG) covalently attached to SiNPs may improve the (bio)compatibility, solubility in water and stability of SiNPs, without inhibiting their optical properties. SiNPs are first coated with silica followed by a silanization of the surface. Then, two versatile “grafting to” methods are used to provide pegylated SiNPs. Both peptide type coupling and copper(I)‐catalyzed azide‐alkyne cycloaddition (CuAAC) are conducted and compared to graft PEG of different chain lengths. Infra‐red spectroscopy, thermogravimetric analysis and transmission electron microscopy prove that theses methodologies are simple and efficient for the preparation of functional inorganic nanoparticles with luminescent properties.