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pH‐Responsive Double‐Hydrophilic Block Copolymers: Synthesis and Drug Delivery Application
Author(s) -
Dai XiaoHui,
Hong ChunYan,
Pan CaiYuan
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200324
Subject(s) - copolymer , polymer chemistry , micelle , chemistry , pyrene , aqueous solution , raft , polymerization , amphiphile , organic chemistry , polymer
A novel double‐hydrophilic block copolymer P(MEO 2 MA‐ co ‐OEGMA)‐ b ‐PAMA has been successfully synthesized by two‐step RAFT polymerization. Then, the amino groups of PAMA blocks in the copolymers react with 1‐pyrenecarboxaldehyde via a “Schiff‐base” reaction, and the resulting copolymers are self‐assembled to form spherical micelles in aqueous solution. Because the “Schiff‐base” linkage is pH sensitive, the release rate of pyrene depends upon the pH of solution. Complete release is achieved at pH 1, and the control release is much faster at pH 5.5 than that at pH 7.4. With progress of pyrene release, the micelles are disassembled gradually and disappeared completely at last. This double‐hydrophilic copolymer is a promising candidate of drug carrier for the aldehyde‐ containing hydrophobic drugs.