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Facile Surface Modification and Application of Temperature Responsive Poly( N ‐isopropylacrylamide‐ co ‐dopamine methacrylamide)
Author(s) -
Park Jung Kyu,
Kim Ki Su,
Yeom Junseok,
Jung Ho Sang,
Hahn Sei Kwang
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200308
Subject(s) - methacrylamide , poly(n isopropylacrylamide) , lower critical solution temperature , polymer chemistry , chemistry , surface modification , copolymer , polymer , materials science , chemical engineering , acrylamide , organic chemistry , engineering
The temperature‐responsive poly(N‐isopropylacrylamide) [PNIPAAm] has been exploited for various biomedical applications. In this work, poly(N‐isopropylacrylamide‐ co ‐dopamine methacrylamide) [P(NIPAAm‐ co ‐DMAAm)] was synthesized for facile surface modification and application to cell sheets. 1 H NMR, FT‐IR, and GPC confirmed the successful synthesis of P(NIPAAm‐ co ‐DMAAm). The lower critical solution temperature was measured to be ca. 29.2 °C by UV–Vis spectroscopy. AFM imaging clearly visualized the transient phase transition of the temperature‐responsive polymer bound on silicon substrate by coordination bond formation. Furthermore, the adhesive and temperature responsive P(NIPAAm‐ co ‐DMAAm) could be successfully applied to the facile preparation of NIH‐3T3 fibroblast cell sheets.