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Surface Engineering of Poly(ethylene terephthalate) for Durable Hemocompatibility via a Surface Interpenetrating Network Technique
Author(s) -
Li Jiang,
Lin Francis,
Li Lingdong,
Li Jing,
Liu Song
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200251
Subject(s) - heparin , nuclear chemistry , surface modification , materials science , adhesion , fourier transform infrared spectroscopy , platelet adhesion , polymer chemistry , inert , leaching (pedology) , covalent bond , substrate (aquarium) , chemistry , biomedical engineering , chemical engineering , composite material , organic chemistry , biochemistry , medicine , engineering , environmental science , oceanography , soil science , soil water , geology
Heparin was covalently bonded on chemically inert PET substrate using a surface modification technique–surface interpenetrating network with the purpose of fabricating long‐lasting biocompatible materials as vascular grafts. FTIR and XPS spectra confirmed the successful heparinization of PET (PET‐Hep). The density of surface‐immobilized heparin as quantified by a colorimetric method could reach 2.4 μg cm −2 (in the reported optimal range: 1.5–3.0 μg cm −2 ). The hemocompatibility of the heparin‐immobilized PET was improved as evidenced by a platelet adhesion test: significantly less platelet adhesion on PET‐Hep (11.60%) than on untreated PET (48.91%). An MTT assay indicated PET‐Hep was nontoxic to human dermal fibroblast cells. After an initial 5.24% loss of heparin from PET‐Hep in the first 14 h immersion in PBS buffer solution, no further leaching of heparin was found.