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Functional Poly(Dimethyl Aminoethyl Methacrylate) by Combination of Radical Ring‐Opening Polymerization and Click Chemistry for Biomedical Applications
Author(s) -
Maji Samarendra,
Mitschang Fabian,
Chen Lina,
Jin Qiao,
Wang Youxiang,
Agarwal Seema
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200220
Subject(s) - polymer chemistry , click chemistry , chemistry , propargyl , acrylate , ethylene glycol , polymerization , radical polymerization , cationic polymerization , methacrylate , copolymer , ring opening polymerization , polymer , organic chemistry , catalysis
In this work, the macromolecular design and modular synthesis of degradable and biocompatible copolymers via radical polymerization and click chemistry is highlighted and the resulting systems are evaluated as gene delivery carriers. Poly(ethylene glycol) (PEG) grafted poly[2‐methylene‐1,3‐dioxepane (MDO)‐ co ‐propargyl acrylate (PA)‐ co ‐2‐(dimethyl aminoethyl methacrylate (DMAEMA)] (MPD) is synthesized using radical polymerization and azide‐alkyne click chemistry. The polymers are less cytotoxic and are able to condense plasmid DNA into nanosized particles. The low transfection efficiency of polyplexes in HepG2 cells is significantly improved by mixing Tat peptide with polyplexes.