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Copolymer Composition Determined by LC‐MALDI‐TOF MS Coupling and “MassChrom2D” Data Analysis
Author(s) -
Weidner Steffen M.,
Falkenhagen Jana,
Bressler Ingo
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200169
Subject(s) - copolymer , fractionation , chemistry , mass spectrometry , electrospray , chromatography , analytical chemistry (journal) , fraction (chemistry) , mass spectrum , organic chemistry , polymer
The MALDI‐TOF MS analysis of copolymers very often results in complex spectra. A chromatographic separation/fractionation prior to the MALDI investigation can be advantageous since the MALDI mass spectra of fractions very often reveal well‐resolved peaks of distinguishable copolymer series. For this purpose, different modes of chromatography have been applied. Chromatographic runs were transferred to MALDI targets utilizing a combined air/electrospray deposition device. Using the new MassChrom2D software, fraction‐dependent 2D copolymer compositions plots were obtained providing additional information on the chromatographic mode, and enabling fast modification of conditions to increase separation.