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Modification of Microbial Polymalic Acid With Hydrophobic Amino Acids for Drug‐Releasing Nanoparticles
Author(s) -
LanzLandázuri Alberto,
GarcíaAlvarez Montserrat,
PortillaArias José,
de Ilarduya Antxon Martínez,
Holler Eggehard,
Ljubimova Julia,
MuñozGuerra Sebastián
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201200134
Subject(s) - copolymer , chemistry , hydrolysis , phenylalanine , polymer chemistry , nanoparticle , aqueous solution , doxorubicin , nuclear chemistry , amino acid , organic chemistry , polymer , biochemistry , nanotechnology , materials science , medicine , surgery , chemotherapy
Microbial poly( β , L ‐malic acid) was modified with either L ‐leucine ethyl ester (L) or L ‐phenylalanine methyl ester (F) to produce amphiphylic copolymers. The degradation of these copolymers in aqueous buffer took place under physiological conditions in a few weeks by hydrolysis of the side chain ester group followed by cleavage of the main chain. Spherical nanoparticles with diameters ranging between 70 and 230 nm were prepared from these copolymers by the dialysis‐precipitation method. No alteration of the cell viability was observed after incubation of these nanoparticles in different cell lines. Anticancer drugs temozolomide and doxorubicin were encapsulated in the nanoparticles. Temozolomide was released within several hours whereas doxorubicin took several weeks to be completely liberated.