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Rapid and Tunable Reductive Degradation of Disulfide‐Labeled Polyesters
Author(s) -
Pinnel Patrick,
MendezNelson Andrew,
Noh Seung Man,
Nam Joon Hyun,
Oh Jung Kwon
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201100662
Subject(s) - polyester , degradation (telecommunications) , disulfide bond , condensation polymer , chemistry , polymer chemistry , polymer , organic chemistry , telecommunications , biochemistry , computer science
A new approach for rapid and tunable degradation of reductively degradable polyesters (ssPESs) with multiple disulfides on the polymer backbones is reported. The approach centers on the control of the amount of disulfides in the synthesis of ssPESs by polycondensation of a disulfide‐containing diacid with various single and mixed diols having different molecular weights and disulfides. The disulfide concentration in ssPESs is tuned by incorporation of diols labeled with disulfides or diols with different MWs. The degradation rate is enhanced with increasing ssPES molecular weight. With ssPESs bearing disulfides positioned repeatedly along the backbone, the rapid and controlled degradation is compared with the slow degradation of polyesters with only a single disulfide in the center.