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In Situ Forming Poly(ethylene glycol)‐ Poly( L ‐lactide) Hydrogels via Michael Addition: Mechanical Properties, Degradation, and Protein Release
Author(s) -
Buwalda Sytze J.,
Dijkstra Pieter J.,
Feijen Jan
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201100640
Subject(s) - peg ratio , ethylene glycol , self healing hydrogels , polymer chemistry , copolymer , macromonomer , chemistry , lysozyme , acrylate , polyethylene glycol , materials science , polymer , organic chemistry , biochemistry , finance , economics
Chemically crosslinked hydrogels are prepared at remarkably low macromonomer concentrations from 8‐arm poly(ethylene glycol)‐poly( L ‐lactide) star block copolymers bearing acrylate end groups (PEG‐(PLLA n ) 8 ‐AC, n = 4 or 12) and multifunctional PEG thiols (PEG‐(SH) n , n = 2, 4, or 8) through a Michael‐type addition reaction. Hydrogels are obtained within 1 min after mixing PEG‐(PLLA 4 ) 8 ‐AC and PEG‐(SH) 8 in phosphate buffered saline, quickly reaching a high storage modulus of 17 kPa. Lysozyme and albumin are released for 4 weeks from PEG‐(PLLA 12 ) 8 ‐AC/PEG‐(SH) 8 hydrogels. Lysozyme release from PEG‐(PLLA 12 ) 8 ‐AC/PEG‐(SH) 2 and PEG‐(PLLA 12 ) 8 ‐AC/PEG‐(SH) 4 hydrogels is significantly faster with complete release in 3 and 12 d, respectively, as a result of a combination of degradation and diffusion.