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Physicochemical Properties and Bioactivity of a Novel Class of Cellulosics: 6‐Deoxy‐6‐amino Cellulose Sulfate
Author(s) -
Genco Taha,
Zemljič Lidija Fras,
Bračič Matej,
StanaKleinschek Karin,
Heinze Thomas
Publication year - 2012
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201100571
Subject(s) - titration , chemistry , sulfate , cellulose , protonation , deprotonation , polyelectrolyte , polymer chemistry , conductometry , carboxymethyl cellulose , organic chemistry , inorganic chemistry , polymer , sodium , ion
The physicochemical behavior with emphasis on the charging behavior of 6‐deoxy‐6‐(2‐(bis(2‐aminoethyl)aminoethyl‐amino) cellulose sulfate (BAECS) with degree of substitution (DS) of 1.31 (sulfate moieties) and 0.71 (amino moieties) and of 6‐deoxy‐6‐(2‐aminoethyl) cellulose sulfate (AECS, DS Sulf = 1.41, DS DAE = 0.85, DS Tosyl ≈0.09) is studied by using several types of titrations. The amounts of protonated amino groups determined by conductometric titration are 4.02 and 2.53 mmol g −1 for BAECS and AECS, respectively. The amino groups are fully deprotonated at pH ≥ 11, whereas the sulfate moieties determined by polyelectrolyte titration are fully dissociated at this pH value. Furthermore, studies on the antimicrobial and antithrombogenetic efficiencies of the samples are carried out.