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SPR Detection of Dopamine Using Cathodically Electropolymerized, Molecularly Imprinted Poly‐ p ‐aminostyrene Thin Films
Author(s) -
Dutta Pampa,
Pernites Roderick B.,
Danda Chaitanya,
Advincula Rigoberto C.
Publication year - 2011
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201100365
Subject(s) - molecularly imprinted polymer , x ray photoelectron spectroscopy , surface plasmon resonance , electrochemistry , monomer , materials science , electrode , polymer , chemical engineering , selectivity , polymer chemistry , nuclear chemistry , chemistry , nanotechnology , nanoparticle , organic chemistry , catalysis , composite material , engineering
A molecularly imprinted polymer (MIP) film for dopamine (DP) sensing is fabricated from cathodically electrodeposited p ‐aminostyrene (PAS) on electrode surfaces in a surface plasmon resonance (SPR) spectroscopy setup. The monomer is more commonly used in monolithic MIP free‐radical bulk polymerizations. The film growth and rebinding of DP are monitored by electrochemical‐SPR (EC‐SPR) spectroscopy. UV–Vis, IR spectroscopy, XPS, AFM, and electrochemistry methods are used to characterize the film. High selectivity against analogous analytes and up to picomolar detection of DP is demonstrated. The reusability of the sensor is also established. Theoretical modeling studies with AM1 calculations predict H‐bonding in a stable prepolymerization complex in solution prior to MIP film formation.