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Effects of pH‐Sensitive Groups on Poly(ethylene oxide)‐ block ‐poly(ϵ‐caprolactone) Block Copolymer Micelles Used as Drug Carriers
Author(s) -
Chen Dong,
Liang Huimin,
Yang Yuehui,
Yuan Zhenting,
Ding Pingtian,
Deng Yihui
Publication year - 2011
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201100351
Subject(s) - micelle , copolymer , methacrylic acid , ethylene oxide , chemistry , polymer chemistry , poly(methacrylic acid) , ethylene glycol , caprolactone , acrylic acid , amphiphile , gel permeation chromatography , polymer , methacrylate , nuclear chemistry , aqueous solution , organic chemistry
A new type of drug delivery system consisting of an amphiphilic polymer micelle with pH‐sensitive groups is reported. The polymer comprises mPEG [poly(ethylene glycol) monomethyl ether], PCL [poly(ϵ‐caprolactone)], and either PAA [poly(acrylic acid)] or PMAA [poly(methacrylic acid)]. Both mPEG ‐b‐ PCL and mPEG ‐b‐ PCL ‐b‐ PAA/PMAA are characterized by 1 H NMR, FTIR, and gel permeation chromatography (GPC). The diameters of the mPEG ‐b‐ PCL ‐b‐ PAA/PMAA micelles are found to increase with increases in pH and studies show that in vitro release of nifedipine from mPEG ‐b‐ PCL ‐b‐ PAA/PMAA micelles becomes faster as the pH value of phosphate‐buffered saline (PBS) increases. This new type of pH‐sensitive polymeric micelle can potentially be used as a drug carrier for oral administration of water‐insoluble drugs.