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Backbone‐Thermoresponsive Hyperbranched Polyglycerol by Random Copolymerization of Glycidol and 3‐Methyl‐3‐(hydroxymethyl)oxetane
Author(s) -
Xia Yumin,
Wang Yimin,
Wang Yanping,
Wang Dali,
Deng Hongping,
Zhuang Yuanyuan,
Yan Deyue,
Zhu Bangshang,
Zhu Xinyuan
Publication year - 2011
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201100077
Subject(s) - glycidol , oxetane , lower critical solution temperature , hydroxymethyl , polymer chemistry , copolymer , chemistry , polymer , organic chemistry , catalysis
The hyperbranched polyglycerol analog, hyperbranched poly[glycerol‐ co ‐3‐methyl‐3‐(hydroxymethyl)oxetane] [HP(G‐ co ‐M)], was synthesized in one‐step by random copolymerization of glycidol and 3‐methyl‐3‐(hydroxymethyl)oxetane (MHO). The obtained polymer exhibited a thermoresponsive behavior in an aqueous solution, and the corresponding lower critical solution temperature (LCST) could be readily adjusted by changing the feed ratio of glycidol to MHO. The MTT assay against COS‐7 cells demonstrated that HP(G‐ co ‐M) had low cytotoxicity. Moreover, the existence of numerous hydroxyl terminals of HP(G‐ co ‐M) facilitated their further modification and functionalization. All of these characteristics suggest that this novel backbone‐thermoresponsive hyperbranched polyglycerol is a promising functional material for biomedical applications.