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Statistical Glycopolymers Based on 2‐Hydroxyethyl Methacrylate: Copolymerization, Thermal Properties, and Lectin Interaction Studies
Author(s) -
Bordegé Vanesa,
MuñozBonilla Alexandra,
León Orietta,
CuervoRodríguez Rocío,
SánchezChaves Manuel,
FernándezGarcía Marta
Publication year - 2011
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201100014
Subject(s) - polymer chemistry , copolymer , methacrylate , monomer , thermal stability , chemistry , acrylate , glass transition , reactivity (psychology) , radical polymerization , amphiphile , methyl methacrylate , polymerization , organic chemistry , polymer , medicine , alternative medicine , pathology
Amphiphilic statistical glycopolymers based on unprotected glycomonomer, 2‐{[( D ‐glucosamin‐2‐ N ‐yl)carbonyl]oxy}ethyl methacrylate (HEMAGl), and methyl acrylate have been synthesized by classical free radical polymerization in DMSO solutions at 70 °C. The reactions have been followed by in situ monitoring proton NMR. The monomer reactivity ratios have been calculated using Kelen‐Tüdös extended equation. Then, the cumulative feed and copolymer compositions as a function of conversion have been obtained, showing a good agreement between the experimental and theoretical data. The thermal properties such as their glass transition and thermal stability temperatures have been analyzed. In addition, the carbohydrate–lectin interaction in those water‐soluble glycopolymers has been studied, demonstrating successful binding.