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A Convenient Method for the Synthesis of the Amphiphilic Triblock Copolymer Poly( L ‐lactic acid) ‐block‐ Poly( L ‐lysine) ‐block‐ Poly(ethylene glycol) Monomethyl Ether
Author(s) -
Xiang Li,
Shen LinJing,
Long Feng,
Yang Ke,
Fan JunBing,
Li YaJing,
Xiang Jiannan,
Zhu MingQiang
Publication year - 2011
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201000717
Subject(s) - copolymer , amphiphile , micelle , polymer chemistry , ethylene glycol , polymer , chemistry , acylation , materials science , aqueous solution , organic chemistry , catalysis
The amphiphilic triblock copolymer PLA ‐b‐ PLL ‐b‐ MPEG is prepared in three steps through acylation coupling between the terminal amino groups of PLA ‐b‐ PZLL‐NH 2 and carboxyl‐terminal MPEG, followed by the deprotection of amines. The block copolymers are characterized via FT‐IR, 1 H NMR, DSC, GPC, and TEM. TEM analysis shows that the triblock polymers can form polymeric micelles in aqueous solution with a homogeneous spherical morphology. The cytotoxicity assay indicates that the final triblock polymer micelles after deprotection show low cytotoxicity against Bel7402 human hepatoma cells. MPEG and PLL were introduced into the main chain of PLA affording a kind of ideal bioabsorbable polymer materials, which is expected to be useful in drug and gene delivery.