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Homo and Block Copolymers of Poly( β ‐benzyl‐ L ‐aspartate)s and Poly( γ ‐benzyl‐ L ‐glutamate)s of Different Architectures
Author(s) -
Brulc Blaž,
Žagar Ema,
Gadzinowski Mariusz,
Słomkowski Stanisław,
Žigon Majda
Publication year - 2011
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201000710
Subject(s) - molar mass , chemistry , copolymer , molar ratio , polymer chemistry , polymerization , glutamic acid , hydrochloride , glutamate receptor , amino acid , catalysis , organic chemistry , polymer , receptor , biochemistry
Abstract Homopolypeptides of linear and star‐like architectures were prepared by polymerizing benzylic‐protected L ‐glutamic acid and L ‐aspartic acid N ‐carboxyanhydrides (Glu NCA, Asp NCA) in DMF. The polymerization rate of the Glu NCA is faster than that of Asp NCA. Using a simple monoamino initiator, its hydrochloride, di‐, tri‐, and tetraamino functional initiators, homopolypeptides with well‐defined structures and molar masses were obtained. The molar‐mass averages of the poly( γ ‐benzyl‐ L ‐glutamate)s lie very close to calculated values, according to the initial [M]:[I] ratios, while those of the linear poly( β ‐benzyl‐ L ‐aspartate)s were lower than the predicted ones. PBAs had somewhat broader molar‐mass distributions than PBGs.