Premium
Ultrasound‐Induced Disruption of Amphiphilic Block Copolymer Micelles
Author(s) -
Xuan Juan,
Pelletier Maxime,
Xia Hesheng,
Zhao Yue
Publication year - 2011
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201000624
Subject(s) - micelle , copolymer , amphiphile , aqueous solution , polymer chemistry , materials science , hydrolysis , chemistry , ultrasound , chemical engineering , polymer , organic chemistry , acoustics , engineering , physics
Ultrasound‐induced disruption of PEO‐ b ‐PTHPMA, PEO‐ b ‐PIBMA, PEO‐ b ‐PTHFEMA, and PEO‐ b ‐PMMA block copolymer micelles in aqueous solution was investigated. Fluorescence change of loaded NR, DLS, IR, AFM, and SEM show that those micelles could be disrupted differently by 1.1 MHz high‐intensity focused ultrasound beams. The micelles of PEO‐ b ‐PIBMA and PEO‐ b ‐PTHPMA appear to be more sensitive to ultrasound irradiation, resulting in a more severe micellar disruption, and IR spectra show evidence of ultrasound‐induced chemical reactions, most likely hydrolysis. PEO‐ b ‐PMMA appear to resist HIFU irradiation better, and IR analysis found no evidence of chemical reactions. This study provides new evidence for the prospect of ultrasound‐responsive BCP micelles for controlled delivery applications.