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Disulfide‐Crosslinked Biomimetic Micelles: Formation, Thiol Reactivity and Cytotoxicity Behavior
Author(s) -
Lv LiPing,
Xu JianPing,
Liu XiangSheng,
Liu GongYan,
Yang Xuan,
Ji Jian
Publication year - 2010
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201000458
Subject(s) - micelle , copolymer , nanocarriers , amphiphile , chemistry , polymer chemistry , biocompatibility , reactivity (psychology) , organic chemistry , polymer , drug delivery , aqueous solution , medicine , alternative medicine , pathology
A series of amphiphilic random copolymers with MPC as the hydrophilic segment, SMA as the hydrophobic segment and GMA as the reactive segment were synthesized. Polymeric micelles with different sizes were obtained through tuning the hydrophilic/hydrophobic segment ratios in the copolymers. The formation and properties of these micelles were investigated using 1 H NMR spectroscopy, fluorescence probe techniques and DLS. The reactive polymeric micelles were crosslinked with a di‐functional reagent. The crosslinked micelles showed improved stability and thiol reactivity. Cell viability tests indicated that the bioinspired phosphorylcholine‐based micelles showed excellent biocompatibility, thus promising great potential for applications in the field of nanocarrier systems.