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A Polymeric Drug Depot Based on 7‐(2′‐Methacryloyloxyethoxy)‐4‐methylcoumarin Copolymers for Photoinduced Release of 5‐Fluorouracil Designed for the Treatment of Secondary Cataracts
Author(s) -
Sinkel Carsten,
Greiner Andreas,
Agarwal Seema
Publication year - 2010
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201000206
Subject(s) - copolymer , polymer , polymer chemistry , monomer , chemistry , surface modification , drug delivery , polymerization , methacrylate , materials science , chemical engineering , organic chemistry , engineering
Abstract The synthesis of a polymeric, photoresponsive drug‐delivery system on the basis of 4‐methylcoumarin‐side‐chain‐functionalized methacrylic copolymers with different degrees of functionalization is reported. Drug‐release experiments in solution indicated a maximum release of 22 µg of 5‐fluorouracil per 1 mg of polymer. Polymer analogous photochemical drug immobilization does not lead to observable intermolecular cross‐linking. Miscibility experiments with PMMA suggest that the bulk polymerization of homogeneous, transparent polymer sheets for intraocular lens fabrication, using MMA as the matrix monomer and incorporating the polymer‐drug conjugates as a functional component, is possible.