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Synthesis of Photocleavable Amphiphilic Block Copolymers: Toward the Design of Photosensitive Nanocarriers
Author(s) -
Cabane Etienne,
Malinova Violeta,
Meier Wolfgang
Publication year - 2010
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.201000151
Subject(s) - copolymer , nanocarriers , amphiphile , micelle , polymer chemistry , polymer , chemistry , linker , materials science , nanoparticle , nanotechnology , organic chemistry , aqueous solution , computer science , operating system
The synthesis of a novel amphiphilic block copolymer containing a photodegradable linker as a junction point between hydrophilic and hydrophobic chains is presented. PmCL–ONB – PAA block copolymers were synthesized via a combination of ROP and ATRP from a difunctional photoresponsive initiator (ONB). The copolymers are biodegradable and biocompatible, they can self‐assemble into different structures, including micelles and vesicles which are photoresponsive. When polymer solutions were exposed to UV we observed significant changes in size and number of particles. We are currently investigating the promising potential of this system as photosensitive nanocarrier.