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Fluorinated Polymer Nanoparticles as a Novel 19 F MRI Contrast Agent Prepared by Dendrimer‐Initiated Living Radical Polymerization
Author(s) -
Ogawa Michihiro,
Nitahara Satoshi,
Aoki Hiroyuki,
Ito Shinzaburo,
Narazaki Michiko,
Matsuda Tetsuya
Publication year - 2010
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.200900672
Subject(s) - dendrimer , polymer chemistry , polymerization , polymer , radical polymerization , methacrylate , nanoparticle , chemistry , materials science , organic chemistry , nanotechnology
Novel fluorinated polymer nanoparticles (PNPs) for 19 F MRI were prepared by living radical polymerization initiated by a dendrimer. The dendritic macroinitiator with Br substituents was synthesized from hydroxy‐group‐terminated G2 polyamidoamine dendrimers. The arborescent fluorinated polymers of 2,2,3,3‐tetrafluoropropyl methacrylate and 2,2,2‐trifluoroethyl methacrylate were characterized in molecular weight, the number of arms, the degree of polymerization per arm, and the diameter as a whole. The PNP diameter was precisely controlled by the molecular weight in the range of 3–25 nm. In addition, the fluorinated PNP gave a narrow resonance by 19 F NMR spectroscopy. These results indicate that the fluorinated PNP can be used as a new type of 19 F MRI agent.