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New Amphiphilic Conjugates of Mono‐ and Bis(carboxy)‐PEG 2,000 Polymers with Lipoamino Acids as Surface Modifiers of Colloidal Drug Carriers
Author(s) -
Pignatello Rosario,
Pantò Valentina,
Basile Livia,
Impallomeni Giuseppe,
Ballistreri Alberto,
Pistarà Venerando,
Craparo Emanuela F.,
Puglisi Giovanni
Publication year - 2010
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.200900632
Subject(s) - peg ratio , nanocarriers , chemistry , amphiphile , zeta potential , polymer , liposome , conjugate , solubility , colloid , drug delivery , nanoparticle , drug carrier , combinatorial chemistry , polymer chemistry , organic chemistry , copolymer , nanotechnology , materials science , biochemistry , mathematical analysis , mathematics , finance , economics
Linking PEG 2,000 polymers ending in 1 or 2 carboxylic groups to lipoamino acids (LAAs) gives mono‐ and homo‐disubstituted PEG‐LAA conjugates. They show an identical solubility to parent PEGs in water and organic solvents. By DSC the degree and depth of interaction of these conjugates with a biomembrane model is studied, gaining information about their future incorporation in drug‐loaded nanocarriers. The ability of PEG‐LAA conjugates to adopt an ordinate arrangement on the surface of particles and efficiently cover them is demonstrated, compared to DSPE‐PEG, by measuring the zeta potential values of negatively charged liposomes prepared in their presence.