Premium
In Vitro Study of Dexamethasone Release From Poly( p ‐xylylene) Films
Author(s) -
Hanefeld Phillip,
Agarwal Seema,
Kumar Rakesh,
Greiner Andreas
Publication year - 2010
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.200900537
Subject(s) - restenosis , materials science , percutaneous transluminal coronary angioplasty , xylylene , dexamethasone , in vitro , biocompatible material , polymer chemistry , chemistry , chemical engineering , biomedical engineering , stent , surgery , medicine , biochemistry , artery , engineering
Stents or metal endoprotheses are currently used to prevent restenosis after percutaneous transluminal angioplasty (PTA). Recently multi‐component systems comprising implant applications, e. g., stents, protective and/or a drug containing layers, have found wide‐spread application. Permanent and biocompatible stent coatings based on poly( p ‐xylylene) (PPX) films were investigated for their potential to form drug containing reservoirs. The model drug dexamethasone was loaded into films of PPX by solvent treatment. Loading efficiency and in vitro drug release profiles were studied under physiological conditions. Linear release of dexamethasone was observed when PPX/dexamethasone films were coated by an additional PPX film as cover layer.