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Synthesis of a pH‐Sensitive PEO‐Based Block Copolymer and its Application for the Stabilization of Iron Oxide Nanoparticles
Author(s) -
Kim Keunsuk,
Kim Tae Hwan,
Choi Jin Hee,
Lee Jae Yeol,
Hah Sang Soo,
Yoo HyunOh,
Hwang Seung Sang,
Ryu Kyeong Nam,
Kim Hyeong Joong,
Kim Jungahn
Publication year - 2010
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.200900528
Subject(s) - copolymer , amphiphile , transmission electron microscopy , nanoparticle , superparamagnetism , materials science , aqueous solution , polymer chemistry , iron oxide nanoparticles , oxide , iron oxide , chemistry , chemical engineering , magnetization , nanotechnology , organic chemistry , polymer , physics , quantum mechanics , magnetic field , engineering
PEO‐based amphiphilic block copolymers that exhibit a pH responsive phase transition behavior are synthesized. The amphiphilic block copolymers show sharp phase transitions in the physiological pH (7.2) range of aqueous media. The block copolymers were efficient stabilizers for the preparation of superparamagnetic iron oxide nanoparticles in aqueous media. The resulting iron oxide nanoparticles in the size range of 5–30 nm showed a relatively good $T_2^* $ image on the basis of the results on their phantom test. All the materials were characterized by the combination of 1 H NMR spectroscopy, size exclusion chromatography, UV/visible spectroscopic analysis, magnetization, transmission electron microscopy, electron diffraction, and X‐ray diffraction pattern analysis.