Premium
Amphiphilic Hyperbranched Polymers Containing Two Types of β ‐Cyclodextrin Segments: Synthesis and Properties
Author(s) -
Tian Wei,
Fan XiaoDong,
Kong Jie,
Liu YuYang,
Zhang WeiHong,
Cheng GuangWen,
Jiang Min
Publication year - 2009
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.200900399
Subject(s) - atom transfer radical polymerization , cyclodextrin , amphiphile , polymer , chemistry , polymer chemistry , molecule , covalent bond , ionic bonding , polymerization , radical polymerization , ultraviolet visible spectroscopy , double bond , chemical engineering , organic chemistry , copolymer , ion , engineering
Amphiphilic hyperbranched polymers carrying two types of β ‐cyclodextrin groups including ionic and covalent bonding were synthesized via atom transfer radical polymerization and immobilization reaction. Their inclusion capabilities for single or double‐guest molecules were investigated by UV‐visible spectroscopy. Using Chlorambucil and Lonidamine as the double model drugs, their encapsulation efficiencies indicate that these polymers possess the capabilities of high drug‐loading. Furthermore, the release behaviors of these polymers were studied via UV‐visible spectroscopy. The results indicate that they can slow the release rate of double model drugs. Varying the pH values of environment or regulating their shell layer structures can control the release behaviors of double model drugs.