Premium
Novel Biodegradable Heterografted Polymer Brushes Prepared via a Chemoenzymatic Approach
Author(s) -
Hans Marc,
Xiao Yan,
Keul Helmut,
Heise Andreas,
Moeller Martin
Publication year - 2009
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.200800590
Subject(s) - polymer chemistry , polymerization , ring opening polymerization , vinyl acetate , acrylate , polymer , bottle , chemistry , copolymer , materials science , organic chemistry , composite material
Biodegradable heterografted molecular bottle brushes were prepared in two steps starting with a linear polyglycidol as a macroinitiator. First, ca. 45% of the polyglycidol hydroxy groups were grafted with ε ‐caprolactone via enzymatic catalysis. Selective end capping of the hydroxy groups at the graft ends was achieved via enzymatic esterification with vinyl acetate or vinyl acrylate. Finally, poly( L ‐lactide) grafts were attached to the remaining polyglycidol hydroxy groups by chemically catalyzed ring‐opening polymerization. The successful synthesis of the heterografted comb‐shaped brushes was confirmed by NMR and SEC analyses. Additionally, the feasibility of microsphere formulation was described.