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Biotin‐, Pyrene‐, and GRGDS‐Functionalized Polymers and Nanogels via ATRP and End Group Modification
Author(s) -
Siegwart Daniel J.,
Oh Jung Kwon,
Gao Haifeng,
Bencherif Sidi A.,
Perineau Fabien,
Bohaty Andrew K.,
Hollinger Jeffrey O.,
Matyjaszewski Krzysztof
Publication year - 2008
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.200800337
Subject(s) - atom transfer radical polymerization , polymer chemistry , chemistry , miniemulsion , pyrene , polymer , methacrylate , end group , conjugated system , combinatorial chemistry , polymerization , organic chemistry
Functionality, one of the key attributes of atom transfer radical polymerization (ATRP), was utilized for the synthesis of well‐controlled polymers functionalized with biotin, pyrene, and peptides. Hydroxy‐functionalized poly(oligo(ethylene oxide) monomethyl ether methacrylate) (HO‐POEOMA) was prepared by AGET ATRP of OEOMA initiated by 2‐hydroxyethyl 2‐bromoisobutyrate in water or in inverse miniemulsion of water/cyclohexane at ambient temperature. HO‐POEOMA was then further functionalized with biotin, pyrene, and GRGDS peptide. In addition, ATRP and click chemistry offered an efficient route for the synthesis of telechelic di‐biotin polymers. These general methods can be applied to the formation of different functional materials conjugated with proteins, dyes, nucleic acids, and drugs.