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Poly(vinyl alcohol) having amino sugar as the pendant group: Synthesis, characterization and binding of concanavalin A
Author(s) -
GarcíaOteiza Mari Carmen,
SánchezChaves Manuel,
Arranz Felix
Publication year - 1997
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1997.021980718
Subject(s) - vinyl alcohol , polymer chemistry , concanavalin a , sugar , chemistry , group (periodic table) , characterization (materials science) , organic chemistry , materials science , biochemistry , polymer , nanotechnology , in vitro
Poly(vinyl alcohol) (PVAL) samples partially functionalized with 4‐nitrophenyl carbonate groups were obtained by reaction of PVAL with 4‐nitrophenyl chloroformate using pyridine as a catalyst. 2‐Amino‐2‐deoxy‐ D ‐glucose (glucosamine) was virtually quantitatively bound to PVAL activated with 4‐nitrophenyl carbonate groups. Glucosamine‐carrying PVAL (PVAL‐G) and Concanavalin A (Con A) in phosphate buffer (pH 7,2) at room temperature were proven to interact with each other.