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Fixation of pharmacologically active amines on polyphosphonates, 3. Synthesis and preliminary in vitro cytotoxic studies of bis(2‐chloroethyl)amino group containing polyphosphonates
Author(s) -
Fontaine Laurent,
Marbœuf Céline,
Brosse JeanClaude,
Maingault Martine,
Dehaut Frédéric
Publication year - 1996
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1996.021971110
Subject(s) - chemistry , cytotoxic t cell , in vitro , amine gas treating , phosphonate , stereochemistry , chemical modification , cytotoxicity , cell culture , nuclear magnetic resonance spectroscopy , biochemistry , organic chemistry , biology , genetics
Hydrosoluble poly(3,6,9‐trioxaundecamethylene phosphonate) with attached cytotoxic bis(2‐chloroethyl)amine in the side chain was synthesized by chemical modification of the corresponding polyphosphonate via the Atherton‐Todd reaction. The structure of the product was confirmed by 1 H, 13 C and 31 P NMR spectroscopy. Preliminary in vitro cytotoxic studies revealed that the polymeric derivative exhibited an eight fold more cytotoxic potency against human hepatocellular carcinoma cell line HepG2 than against murine leukemia cell line L1210.