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Polymers made from cholic acid derivatives: selected properties
Author(s) -
Zhang Y. H.,
Zhu X. X.
Publication year - 1996
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1996.021971032
Subject(s) - methacrylamide , polymer chemistry , cholic acid , polymer , methacrylate , chemistry , moiety , polymerization , methyl methacrylate , monomer , radical polymerization , methacrylic acid , copolymer , organic chemistry , bile acid , biochemistry , acrylamide
Polymers of methacrylate and methacrylamide derivatives of cholic acid were prepared by free radical polymerization in solution. To verify the stereoisomeric effect of the monomeric units, certain properties of the resulting polymers were compared, including conversion rate, molecular weight, and glass transition temperature. The 3β‐epimers of the methacrylates and methacrylamides are to polymerize more easily than the 3α‐epimers. Water absorption experiments showed that the methacrylamide polymers are more hydrophilic than the methacrylate polymers and that the polymers from the 3β‐epimers have higher hydrophilicity than those made from the 3α‐epimers. The free acid forms of the polymers were also prepared by selective hydrolysis of the methyl ester group of the cholic acid moiety which resulted in improved hydrophilicity of the polymers.