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The effect of alkyl chain length of amphiphilic phospholipid polyurethanes on haemocompatibilities
Author(s) -
Li YuJun,
Bahulekar Raman,
Chen TianMing,
Wang YanFeng,
Kodama Makoto,
Nakaya Tadao
Publication year - 1996
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1996.021970920
Subject(s) - amphiphile , alkyl , phospholipid , polymer chemistry , chain (unit) , chemistry , polymer science , materials science , organic chemistry , polymer , copolymer , membrane , biochemistry , physics , astronomy
A series of phospholipid diols based on different lengths of alkyl chains such as eicosyl, stearyl, cetyl, lauryl, octyl, and butyl was synthesized and characterized. The phospholipid diols were subjected a polyaddition polymerization with hexamethylene diisocyanate. The haemocompatibilities of the resulting phospholipid polyurethanes were evaluated by platelet rich plasma contacting experiments and viewed by scanning electron microscopy. The polymers with alkyl chains of 20, 18, 16, and 12 carbon atoms showed much better haemocompatibilities than those with alkyl chains of 8 and 4 carbon atoms.