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Facile synthesis of new amine high‐loaded poly(meth)acrylamide‐based resins for solid phase peptide
Author(s) -
Alfred JeanClaude,
Daunis Jacques,
Jacquier Robert
Publication year - 1996
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1996.021970130
Subject(s) - acrylamide , moiety , amine gas treating , polymer chemistry , polymerization , chemistry , meth , acryloyl chloride , solid phase synthesis , combinatorial chemistry , organic chemistry , peptide , polymer , copolymer , acrylate , biochemistry
Two methods for the ready preparation of some protected primary amine‐functionalized (meth)acrylamide derivatives from amino halides or amino alcohols are described. The (meth)acryloyl moiety is introduced either in the last step from unsymmetrically N , N ′‐disubstituted diamines or, more simply, in the first step, but that demands a special work‐up of the reaction mixture in order to prevent polymerization. Both methods are complementary. Reverse phase suspension polymerization of the title compounds with N ‐acryloylpyrrolidine and N , N ′‐ethylenebis(acrylamide) directly affords new beaded, high‐loaded aminefunctionalized resins for solid phase peptide synthesis.