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Télomérisation radicalarie de monomères N ‐acryloyl‐ N ‐alkylamino esters d'intXérêt biologique
Author(s) -
Leydet Alain,
Barragan Véronique,
Boyer Bernard,
Roque JeanPierre,
Pucci Bernard,
Pavia André A.
Publication year - 1995
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1995.021961202
Subject(s) - acryloyl chloride , telomerization , chemistry , polymer chemistry , biocompatibility , polymerization , copolymer , organic chemistry , polymer , acrylate , catalysis
Three methyl 11‐( N‐ acryloyl‐ N ‐alkylamino)undecanoates were synthesized from acryloyl chloride and amino‐or alkylaminoundecanoic acid esters. These compounds were telomerized in the presence of 1‐dodecanethiol as telogen to yield telomers with molecular weight lower than 5000. These telomers are likely to generate HIV inhibitor polyanions with good biocompatibility. The K 2 p / K t value was assessed from a kinetic study of the telomerization reaction. NMR spectroscopy analysis indicates that the polymerization degree DP n are in good agreement with expectation for methyl 11‐( N ‐acryloylamino)undecanoate. However, they were lower than expected for methyl 11‐( N ‐acryloyl‐ N ‐alkylamino)undecanoate.