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Télomères et cotéloméres d'intérêt biologique et biomédical, 7 . Synthèse, évaluations physico‐chimiques et biologiques de télomères amphiphiles de type acryloylamino‐acide
Author(s) -
Polidori Ange,
Pucci Bernard,
Pavia André A.,
Lamaty Gérard,
Leydet Alain,
Roque Jean Pierre
Publication year - 1995
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1995.021961123
Subject(s) - chemistry , glycine , amino acid , monomer , alanine , polymer chemistry , polymerization , stereochemistry , organic chemistry , biochemistry , polymer
New ionic telomeric surfactants derived from acryloylamino acids were synthesized and their tensioactive properties compared to those of non‐ionic analogs previously reported. We also compared their anti HIV behavior with that of other polymeric polyanionic derivatives. Acryloyl monomers of various amino acids such as glycine, alanine, aspartic, glutamic and γ‐aminobutyric acid were prepared and telomerized in the presence of various alkanes or perfluoroalkanethiols as chain transfer reagents. For a given amino acid, the critical micellar concentration (CMC) was shown to depend upon the nature and the length of the hydrophobic tail and not the size of the hydrophilic head, i.e., the number average degree of polymerization ( DP n ). None of the telomeric polyanionic derivatives reported herein induced HIV inhibition.