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Novel types of polysaccharidic assemblies
Author(s) -
Crescenzi Vittorio,
Imbriaco David,
Velàsquez Cristòbal Làrez,
Dentini Mariella,
Ciferri Alberto
Publication year - 1995
Publication title -
macromolecular chemistry and physics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.57
H-Index - 112
eISSN - 1521-3935
pISSN - 1022-1352
DOI - 10.1002/macp.1995.021960912
Subject(s) - micelle , self healing hydrogels , macromolecule , polyelectrolyte , biocompatible material , chemistry , amphiphile , chemical engineering , chitosan , polysaccharide , drug carrier , polymer chemistry , drug delivery , polymer science , copolymer , organic chemistry , polymer , aqueous solution , biochemistry , medicine , biomedical engineering , engineering
New types of polysaccharidic assemblies based on chitosan and uncharged or charged derivatives of scleroglucan are presented. Macroscopic assemblies having a spherical skinlike shape were prepared by controlled mixing of two polyelectrolyte solutions. Hydrogels based exclusively on the above natural derivatized polysaccharides crosslinked via simple chemical processes, avoiding the use of extraneous reticulating agents and organic solvents, are also described. These biocompatible materials may, eventually, be used in drug release formulations or for the incapsulation of bioactive macromolecules. The interesting possibility exists to study the micelle formation of amphiphiles within the spherical skins.